PDE6A

Across TCGA patient cohorts, PDE6A mutation is significantly associated with the RNA expression of many other genes, with 2,537 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE6A-associated genes across cancer lineages are PPP2R2D, MAP3K9, and EXD2. Each is linked with PDE6A in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE6A-to-partner and partner-to-PDE6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R2D grouped by PDE6A-low versus PDE6A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6A→partner) and Y-score (partner→PDE6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP2R2D →	+0.249	+2.970	.002	<.001	3	3
UCEC	MAP3K9 →	+0.521	+1.793	<.001	.003	3	3
UCEC	EXD2 →	+0.346	+2.016	.004	.001	3	3
UCEC	BMS1P20 →	+0.326	+1.858	.004	.004	3	3
SKCM	RNA5SP519 →	+0.112	+2.426	<.001	.008	3	3
UCEC	CCL5 →	+0.858	+3.103	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,537 associations by consensus.

PPP2R2D by PDE6A expression — UCEC

Explore this box plot interactively →