PDE6A

Across TCGA cell cohorts, PDE6A RNA expression is significantly associated with the RNA expression of many other genes, with 4,917 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PDE6A-associated genes across cancer lineages are SLC26A2, TMEM45A, and PAPLN. Each is linked with PDE6A in more than 7 cancer types. Because this analysis shows association rather than direction, both PDE6A-to-partner and partner-to-PDE6A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE6A versus SLC26A2 in OVARY, with a Pearson correlation of 0.44.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6A→partner) and Y-score (partner→PDE6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC26A2 →	+2.094	+0.398	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	TMEM45A →	+2.018	+0.233	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PAPLN →	+1.983	+0.283	.001	.001	3	4
BLOOD_Leukemia	SLC2A14 →	+0.933	+0.081	<.001	.001	3	3
LUNG_NSCLC_LUAD	SPACA6 →	+1.135	+0.265	<.001	<.001	3	3
OVARY	LBH →	+3.188	+0.396	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,917 associations by consensus.

PDE6A vs SLC26A2 — OVARY

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