PDE6A

Across TCGA cell cohorts, PDE6A mutation is significantly associated with the RNA expression of many other genes, with 144 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE6A-associated genes across cancer lineages are IQCF6, CD300H, and LYZL2. Each is linked with PDE6A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE6A-to-partner and partner-to-PDE6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF6 grouped by PDE6A-low versus PDE6A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6A→partner) and Y-score (partner→PDE6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IQCF6 →	+0.132	+2.397	.002	.003	3	2
LARGE_INTESTINE	CD300H →	+0.018	+2.830	<.001	.004	3	2
LUNG_SCLC	LYZL2 →	+0.020	+4.643	<.001	.004	3	2
LUNG_NSCLC_LUAD	AVP →	+0.027	+3.734	.004	.006	3	1
LUNG_NSCLC_LUAD	GALR1 →	+0.032	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	FAM216B →	+0.476	+3.544	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

IQCF6 by PDE6A expression — LARGE_INTESTINE

Explore this box plot interactively →