PDE4DIPP4

Across TCGA pan-cancer cohorts, PDE4DIPP4 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated PDE4DIPP4 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PDE4DIPP4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PDE4DIPP4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CHOL show a favorable association.

HNSC, COAD, and ACC are the cancer types where PDE4DIPP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.480	0.282	<.001	102	view →
COAD	OS	Tertile	IV	0.384	0.726	.009	60	view →
ACC	DFS	Tertile	III,IV	0.326	0.722	.006	36	view →
MESO	DFS	Tertile	All	0.130	0.546	<.001	33	view →
UCEC	OS	Tertile	IV	0.250	0.629	.015	24	view →
LUAD	DFS	Quartile	IV	0.323	0.723	.022	18	view →
LIHC	OS	Tertile	All	0.582	0.725	.022	15	view →
CHOL	DFS	Median	II,III,IV	0.541	0.127	.014	13	view →
BLCA	OS	Median	III,IV	0.627	0.497	.007	11	view →
SKCM	OS	Median	IV	0.851	0.293	.030	9	view →
STAD	DFS	Quartile	All	0.267	0.437	.011	9	view →
LGG	DFS	Tertile	All	0.402	0.637	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

PDE4DIPP4–HNSC (DFS)

Open the HNSC breakdown →