PDE4DIPP2

Across TCGA pan-cancer cohorts, PDE4DIPP2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PDE4DIPP2 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PDE4DIPP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDE4DIPP2 expression acts as an unfavorable survival marker, although some lineages such as THCA and BRCA show a favorable association.

LUSC, KIRC, and CESC are the cancer types where PDE4DIPP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.280	0.502	.001	57	view →
KIRC	DFS	Tertile	All	0.509	0.735	<.001	51	view →
CESC	DFS	Median	III,IV	0.464	0.796	.003	32	view →
LGG	DFS	Median	All	0.671	0.799	<.001	24	view →
THCA	DFS	Median	All	0.934	0.701	.008	21	view →
BRCA	OS	Median	IV	0.957	0.511	.012	20	view →
OV	OS	Quartile	III,IV	0.269	0.412	.004	18	view →
LUAD	OS	Quartile	All	0.822	0.597	.007	18	view →
MESO	OS	Median	All	0.486	0.313	.012	18	view →
UCS	DFS	Tertile	IV	0.942	0.364	.024	14	view →
LAML	DFS	Quartile	All	0.518	0.725	.016	12	view →
UCEC	DFS	Median	II,III,IV	0.655	0.812	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PDE4DIPP2–LUSC (DFS)

Open the LUSC breakdown →