PDE4DIP

Across TCGA pan-cancer cohorts, PDE4DIP Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated PDE4DIP data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher PDE4DIP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PDE4DIP expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THYM, UCEC, and KICH are the cancer types where PDE4DIP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	38	view →
UCEC	DFS	Median	All	0.951	0.608	<.001	36	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
SKCM	DFS	Median	II,III,IV	0.750	0.546	.007	13	view →
BLCA	OS	Median	IV	0.130	0.599	.002	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
STAD	DFS	Median	III,IV	1.000	0.337	.041	5	view →
SCLC	DFS	Median	II,III,IV	0.865	0.548	.027	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
COAD	DFS	Median	III,IV	0.156	0.616	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

PDE4DIP–THYM (OS)

Open the THYM breakdown →