PDE4DIP

Across TCGA pan-cancer cohorts, PDE4DIP mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PDE4DIP data layer compared with 25 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PDE4DIP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PDE4DIP expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where PDE4DIP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.507	0.883	<.001	24	view →
LSCC	DFS	Median	II,III,IV	0.543	0.852	.011	15	view →
CCRCC	DFS	Quartile	All	0.705	0.976	.004	14	view →
LUAD	OS	Quartile	III,IV	0.787	0.215	.019	5	view →
GBM	OS	Quartile	All	0.648	0.921	.006	4	view →
UCEC	DFS	Quartile	All	0.962	0.746	.024	4	view →
PDAC	DFS	Tertile	IV	0.558	0.225	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PDE4DIP–HNSC (OS)

Open the HNSC breakdown →