PDE4C

Across TCGA patient cohorts, PDE4C RNA expression is significantly associated with the protein abundance of many other proteins, with 7,827 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PDE4C-associated proteins across cancer lineages are RSL1D1_S427, KANK2, and RBSN. Each is linked with PDE4C in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE4C-to-partner and partner-to-PDE4C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE4C versus RSL1D1_S427 in LSCC, with a Pearson correlation of -0.57.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4C→partner) and Y-score (partner→PDE4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RSL1D1_S427 →	-1.209	-0.125	.003	.001	3	4
UCEC	KANK2 →	+0.797	+0.230	<.001	<.001	3	4
PDAC	RBSN →	+0.182	+0.158	<.001	.003	3	4
PDAC	VILL →	+0.489	+0.104	.002	.004	3	3
UCEC	ZEB2_S731 →	+0.399	+0.167	<.001	<.001	3	3
CCRCC	F13A1 →	+0.484	+0.231	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,827 associations by consensus.

PDE4C vs RSL1D1_S427 — LSCC

Explore this scatter interactively →