PDE4C

Across TCGA patient cohorts, PDE4C mutation is significantly associated with the RNA expression of many other genes, with 3,549 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE4C-associated genes across cancer lineages are FDFT1, CKAP2L, and ESCO2. Each is linked with PDE4C in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE4C-to-partner and partner-to-PDE4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FDFT1 grouped by PDE4C-low versus PDE4C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4C→partner) and Y-score (partner→PDE4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FDFT1 →	+0.508	+2.826	.007	.001	3	4
UCEC	CKAP2L →	+0.520	+2.194	.004	.001	3	4
UCEC	ESCO2 →	+0.628	+2.058	<.001	<.001	3	4
UCEC	KIR2DL4 →	+0.575	+2.415	<.001	.003	3	3
SKCM	SMC3 →	+0.620	+1.916	.007	.009	3	3
UCEC	ZWINT →	+0.692	+3.000	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,549 associations by consensus.

FDFT1 by PDE4C expression — SKCM

Explore this box plot interactively →