PDE4C

Across TCGA cell cohorts, PDE4C RNA expression is significantly associated with the go_rna of many other GO terms, with 1,710 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDE4C-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Cytoplasmic translational initiation, and Positive regulation of double-strand break repair. Each is linked with PDE4C in more than 5 cancer types. Because this analysis shows association rather than direction, both PDE4C-to-partner and partner-to-PDE4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by PDE4C-low versus PDE4C-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4C→partner) and Y-score (partner→PDE4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Pre-mRNA catabolic process →	+0.114	+0.794	<.001	<.001	3	6
LUNG_SCLC	Cytoplasmic translational initiation →	+0.080	+1.203	.001	.001	3	6
STOMACH	Positive regulation of double-strand break repair →	+0.083	+0.915	.007	<.001	3	6
SOFT_TISSUE	Pentose catabolic process →	-0.152	-0.618	<.001	<.001	3	5
SOFT_TISSUE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.125	+0.922	<.001	.002	3	5
SOFT_TISSUE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.091	+0.700	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,710 associations by consensus.

Pre-mRNA catabolic process by PDE4C expression — SOFT_TISSUE

Explore this box plot interactively →