PDE4C

Across TCGA cell cohorts, PDE4C mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PDE4C-associated genes across cancer lineages are ACSM6, HMHB1, and SLC7A13. Each is linked with PDE4C in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE4C-to-partner and partner-to-PDE4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by PDE4C-low versus PDE4C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4C→partner) and Y-score (partner→PDE4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.019	+3.000	.001	.005	3	1
LUNG_NSCLC_LUAD	HMHB1 →	+0.118	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	SLC7A13 →	+0.006	+4.887	.009	.009	3	1
LUNG_NSCLC_LUAD	OR14A2 →	+0.018	+5.228	.001	.005	3	1
SKIN	CASP14 →	+0.160	+3.906	<.001	.005	3	1
SKIN	HOXB1 →	+0.086	+3.155	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ACSM6 by PDE4C expression — LARGE_INTESTINE

Explore this box plot interactively →