PDE4A

Across TCGA patient cohorts, PDE4A mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE4A-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and C-Raf. Each is linked with PDE4A in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE4A-to-partner and partner-to-PDE4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PDE4A-low versus PDE4A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4A→partner) and Y-score (partner→PDE4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.578	+3.169	.001	.018	3	4
COAD	Caspase-7-cleavedD198 →	+1.276	+2.824	<.001	.034	3	3
UCEC	C-Raf →	+0.137	+1.321	.001	.012	3	3
UCEC	EGFR_pY1068 →	-0.226	-1.754	.002	.001	3	2
UCEC	eIF4E →	+0.172	+2.920	.006	<.001	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.448	+1.874	.033	.047	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ASNS by PDE4A expression — COAD

Explore this box plot interactively →