PDE4A

Across TCGA cell cohorts, PDE4A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,572 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PDE4A-associated GO terms across cancer lineages are Positive regulation of neuron migration, rRNA transcription, and IMP biosynthetic process. Each is linked with PDE4A in more than 9 cancer types. Because this analysis shows association rather than direction, both PDE4A-to-partner and partner-to-PDE4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of neuron migration grouped by PDE4A-low versus PDE4A-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4A→partner) and Y-score (partner→PDE4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of neuron migration →	+0.107	+1.787	.004	.002	3	10
BREAST	rRNA transcription →	+0.080	+1.120	<.001	.001	3	9
URINARY_TRACT	IMP biosynthetic process →	+0.179	+1.016	.001	.003	2	10
BREAST	XMP metabolic process →	+0.074	+1.175	<.001	<.001	3	8
BREAST	XMP biosynthetic process →	+0.074	+1.175	<.001	<.001	3	8
BREAST	'de novo' XMP biosynthetic process →	+0.074	+1.175	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,572 associations by consensus.

Positive regulation of neuron migration by PDE4A expression — STOMACH

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