PDE4A

Across TCGA cell cohorts, PDE4A mutation is significantly associated with the RNA expression of many other genes, with 1,195 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDE4A-associated genes across cancer lineages are GPR63, PPP2R5D, and DCTN4. Each is linked with PDE4A in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE4A-to-partner and partner-to-PDE4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR63 grouped by PDE4A-low versus PDE4A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE4A→partner) and Y-score (partner→PDE4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR63 →	+0.985	+3.212	<.001	.006	3	2
LARGE_INTESTINE	PPP2R5D →	+0.666	+3.234	.003	.004	2	3
LARGE_INTESTINE	DCTN4 →	+0.518	+3.299	.002	.004	3	2
LARGE_INTESTINE	FITM1 →	+0.399	+3.299	<.001	.004	3	2
LARGE_INTESTINE	MKX →	+1.848	+3.212	<.001	.006	3	2
LARGE_INTESTINE	SLC16A14 →	+1.164	+3.212	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,195 associations by consensus.

GPR63 by PDE4A expression — LARGE_INTESTINE

Explore this box plot interactively →