PDE3B

Across TCGA pan-cancer cohorts, PDE3B mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PDE3B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PDE3B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PDE3B is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

LSCC, PDAC, and LUAD are the cancer types where PDE3B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDE3B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	II,III,IV	−0.539	<.001	9	view →
PDAC	Male	All	−1.098	<.001	7	view →
LUAD	Male	All	−0.373	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PDE3B–LSCC

Open the LSCC breakdown →