PDE3B

Across TCGA patient cohorts, PDE3B protein abundance is significantly associated with the RNA expression of many other genes, with 3,212 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PDE3B-associated genes across cancer lineages are GABRE, TRIM41, and GRK5. Each is linked with PDE3B in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE3B-to-partner and partner-to-PDE3B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE3B versus GABRE in CCRCC, with a Pearson correlation of -0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE3B→partner) and Y-score (partner→PDE3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GABRE →	-1.612	-0.569	<.001	<.001	3	3
CCRCC	TRIM41 →	-0.452	-0.474	.009	.006	3	3
BRCA	GRK5 →	+0.646	+0.840	.002	.002	3	3
LUAD	FCF1P8 →	-1.029	-0.464	<.001	<.001	3	3
OV	CLIP2 →	-1.566	-0.885	.007	.008	3	2
OV	DUSP3 →	-0.834	-1.166	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,212 associations by consensus.

PDE3B vs GABRE — CCRCC

Explore this scatter interactively →