PDE3B

Across TCGA patient cohorts, PDE3B mutation is significantly associated with the RNA expression of many other genes, with 5,509 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE3B-associated genes across cancer lineages are RIIAD1, NOP10, and UBE2F. Each is linked with PDE3B in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE3B-to-partner and partner-to-PDE3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIIAD1 grouped by PDE3B-low versus PDE3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE3B→partner) and Y-score (partner→PDE3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RIIAD1 →	-0.774	-2.563	<.001	<.001	3	3
UCEC	NOP10 →	+0.499	+2.169	<.001	<.001	3	3
UCEC	UBE2F →	+0.329	+1.980	<.001	<.001	3	3
UCEC	ATL3 →	+0.427	+2.148	<.001	<.001	3	3
UCEC	TAF13 →	+0.544	+1.584	<.001	<.001	3	3
UCEC	RAET1K →	+0.316	+1.609	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,509 associations by consensus.

RIIAD1 by PDE3B expression — UCEC

Explore this box plot interactively →