PDE3B

Across TCGA cell cohorts, PDE3B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,897 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDE3B-associated GO terms across cancer lineages are Blood coagulation, extrinsic pathway, Regulation of positive chemotaxis, and Positive regulation of positive chemotaxis. Each is linked with PDE3B in more than 10 cancer types. Because this analysis shows association rather than direction, both PDE3B-to-partner and partner-to-PDE3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Blood coagulation, extrinsic pathway grouped by PDE3B-low versus PDE3B-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE3B→partner) and Y-score (partner→PDE3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Blood coagulation, extrinsic pathway →	-1.181	-1.550	<.001	<.001	3	11
BONE	Regulation of positive chemotaxis →	-0.247	-1.433	<.001	.001	3	11
BONE	Positive regulation of positive chemotaxis →	-0.225	-1.737	.001	<.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of leukocyte migration →	-0.099	-1.100	.003	.003	3	11
BONE	Negative regulation of cell adhesion →	-0.089	-2.001	<.001	<.001	3	10
PANCREAS	Blood coagulation, intrinsic pathway →	-0.339	-1.532	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,897 associations by consensus.

Blood coagulation, extrinsic pathway by PDE3B expression — OVARY

Explore this box plot interactively →