PDE3B

Across TCGA cell cohorts, PDE3B mutation is significantly associated with the RNA expression of many other genes, with 371 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE3B-associated genes across cancer lineages are MUTYH, SLC25A33, and BANF2. Each is linked with PDE3B in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE3B-to-partner and partner-to-PDE3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MUTYH grouped by PDE3B-low versus PDE3B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE3B→partner) and Y-score (partner→PDE3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MUTYH →	+0.621	+2.502	.004	.005	3	2
LARGE_INTESTINE	SLC25A33 →	+0.512	+3.067	.003	.009	3	2
BLOOD_Lymphoma	BANF2 →	+0.057	+4.058	<.001	.009	3	2
URINARY_TRACT	XAGE5 →	+0.353	+5.087	<.001	.004	3	1
URINARY_TRACT	MPC1L →	+0.083	+5.087	<.001	.004	3	1
URINARY_TRACT	MEIKIN →	+0.476	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 371 associations by consensus.

MUTYH by PDE3B expression — LARGE_INTESTINE

Explore this box plot interactively →