PDE3A

Across TCGA pan-cancer cohorts, PDE3A Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated PDE3A data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PDE3A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PDE3A expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, THCA, and READ are the cancer types where PDE3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.822	.001	36	view →
THCA	DFS	Median	All	0.087	0.896	<.001	24	view →
READ	OS	Median	All	0.166	0.830	<.001	12	view →
KIRP	DFS	Median	All	0.181	0.768	.004	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BRCA	OS	Median	III,IV	0.111	0.544	.029	6	view →
BLCA	OS	Median	IV	1.000	0.322	.028	3	view →
SKCM	DFS	Median	III,IV	0.107	0.662	<.001	3	view →
HNSC	DFS	Median	IV	0.807	0.529	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

PDE3A–UCEC (DFS)

Open the UCEC breakdown →