PDE12

Across TCGA patient cohorts, PDE12 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,931 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PDE12-associated proteins across cancer lineages are QRICH1, DCAF1, and DHX30. Each is linked with PDE12 in more than 5 cancer types. Because this analysis shows association rather than direction, both PDE12-to-partner and partner-to-PDE12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE12 versus QRICH1 in GBM, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE12→partner) and Y-score (partner→PDE12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	QRICH1 →	+0.175	+0.253	.001	<.001	3	6
BRCA	DCAF1 →	+0.319	+0.475	<.001	.001	3	5
LSCC	DHX30 →	+0.215	+0.294	<.001	<.001	3	5
OV	APPL1 →	+0.253	+0.509	.001	.001	2	5
LSCC	PAXBP1 →	+0.275	+0.367	<.001	<.001	3	4
LSCC	PPIB →	-0.381	-0.381	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,931 associations by consensus.

PDE12 vs QRICH1 — GBM

Explore this scatter interactively →