PDE12

Across TCGA patient cohorts, PDE12 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE12-associated genes across cancer lineages are ERK2, FoxM1, and JNK_pT183_Y185. Each is linked with PDE12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE12-to-partner and partner-to-PDE12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PDE12-low versus PDE12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE12→partner) and Y-score (partner→PDE12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.204	+2.999	.012	.035	3	1
UCEC	FoxM1 →	+0.241	+2.331	.028	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.168	-2.321	.018	.034	3	1
UCEC	JNK2 →	+0.281	+2.469	<.001	.010	3	1
UCEC	p62 Lck ligand →	+0.295	+2.999	.033	.035	3	1
UCEC	P-Cadherin →	-0.137	-3.159	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ERK2 by PDE12 expression — UCEC

Explore this box plot interactively →