PDE12

Across TCGA cell cohorts, PDE12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,746 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDE12-associated GO terms across cancer lineages are Mitochondrial mRNA catabolic process, Regulation of mitochondrial mRNA stability, and DNA-templated transcription elongation. Each is linked with PDE12 in more than 17 cancer types. Because this analysis shows association rather than direction, both PDE12-to-partner and partner-to-PDE12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial mRNA catabolic process grouped by PDE12-low versus PDE12-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE12→partner) and Y-score (partner→PDE12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Mitochondrial mRNA catabolic process →	+0.162	+1.088	<.001	<.001	3	18
BLOOD_Myeloma	Regulation of mitochondrial mRNA stability →	+0.152	+1.038	<.001	<.001	3	17
LIVER	DNA-templated transcription elongation →	+0.092	+0.715	<.001	.001	3	15
BLOOD_Myeloma	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.116	+0.686	.005	.002	3	15
BLOOD_Myeloma	rRNA 5'-end processing →	+0.116	+0.686	.005	.002	3	15
BREAST	Positive regulation of mitotic cytokinesis →	+0.182	+0.684	.002	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,746 associations by consensus.

Mitochondrial mRNA catabolic process by PDE12 expression — PANCREAS

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