PDE12

Across TCGA cell cohorts, PDE12 mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE12-associated genes across cancer lineages are DEFA4. Each is linked with PDE12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE12-to-partner and partner-to-PDE12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by PDE12-low versus PDE12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE12→partner) and Y-score (partner→PDE12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

DEFA4 by PDE12 expression — LARGE_INTESTINE

Explore this box plot interactively →