PDE10A

Across TCGA pan-cancer cohorts, PDE10A Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated PDE10A data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher PDE10A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PDE10A expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

ESCA, HNSC, and READ are the cancer types where PDE10A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	All	0.111	0.705	<.001	48	view →
HNSC	OS	Median	All	0.109	0.367	<.001	47	view →
READ	DFS	Median	III,IV	0.132	0.771	<.001	21	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	15	view →
UCEC	OS	Median	IV	0.259	0.770	<.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LUSC	OS	Median	All	0.910	0.768	.035	5	view →
STAD	DFS	Median	III,IV	0.149	0.606	.004	3	view →
LIHC	DFS	Median	II,III,IV	0.044	0.414	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

PDE10A–ESCA (OS)

Open the ESCA breakdown →