PDE10A

mass-spec protein & survival
Survivalmass-specKaplan–Meier · TCGA cohorts

Across TCGA pan-cancer cohorts, PDE10A mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated PDE10A data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PDE10A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PDE10A expression acts as an unfavorable survival marker.

CCRCC are the cancer types where PDE10A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.
LineageMeasureSplitStageAUC1
high
AUC2
low
pSampling consensus
CCRCCOSQuartileAll0.6331.000.0277view →
Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

PDE10A–CCRCC (OS)

Kaplan–Meier survival curve for PDE10A mass-spec protein-high vs -low samples in CCRCC.

Open the CCRCC breakdown →

Exploration