PDE10A

Across TCGA patient cohorts, PDE10A RNA expression is significantly associated with the protein abundance of many other proteins, with 17,344 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PDE10A-associated proteins across cancer lineages are NNMT, CFH, and FERMT2. Each is linked with PDE10A in more than 5 cancer types. Because this analysis shows association rather than direction, both PDE10A-to-partner and partner-to-PDE10A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE10A versus NNMT in OV, with a Pearson correlation of 0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE10A→partner) and Y-score (partner→PDE10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NNMT →	+0.927	+0.451	<.001	<.001	3	6
OV	CFH →	+0.840	+0.651	<.001	<.001	3	6
UCEC	FERMT2 →	+0.552	+0.487	<.001	.002	3	6
BRCA	NID2 →	+0.536	+0.649	<.001	<.001	3	5
OV	P3H1 →	+0.709	+0.492	<.001	<.001	3	5
BRCA	SEC23A →	+0.284	+0.413	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,344 associations by consensus.

PDE10A vs NNMT — OV

Explore this scatter interactively →