PDE10A

Across TCGA patient cohorts, PDE10A mutation is significantly associated with the RNA expression of many other genes, with 3,466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE10A-associated genes across cancer lineages are GTF2E2, KIF18A, and NPEPPS. Each is linked with PDE10A in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE10A-to-partner and partner-to-PDE10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTF2E2 grouped by PDE10A-low versus PDE10A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE10A→partner) and Y-score (partner→PDE10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GTF2E2 →	+0.572	+4.019	<.001	<.001	3	4
UCEC	KIF18A →	+0.485	+1.505	.001	.001	3	4
UCEC	NPEPPS →	+0.356	+1.346	.007	.007	3	4
UCEC	UFD1 →	+0.290	+2.031	<.001	<.001	3	4
UCEC	RAD18 →	+0.304	+1.780	.003	.003	3	4
HNSC	ALMS1-IT1 →	+0.479	+3.528	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,466 associations by consensus.

GTF2E2 by PDE10A expression — SKCM

Explore this box plot interactively →