PDE10A

Across TCGA patient cohorts, PDE10A mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE10A-associated genes across cancer lineages are PDCD4, TFRC, and ASNS. Each is linked with PDE10A in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE10A-to-partner and partner-to-PDE10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PDE10A-low versus PDE10A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE10A→partner) and Y-score (partner→PDE10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.368	-1.142	.009	.048	3	3
UCEC	TFRC →	+0.563	+1.754	<.001	.001	3	3
UCEC	ASNS →	+0.344	+1.502	.001	.027	3	3
LUAD	14-3-3_beta →	-0.154	-1.983	.007	.031	3	2
LUAD	TTF1 →	+0.925	+3.334	.020	.005	3	2
LUAD	Tuberin →	+0.414	+3.807	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

PDCD4 by PDE10A expression — UCEC

Explore this box plot interactively →