PDE10A

Across TCGA cell cohorts, PDE10A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,488 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PDE10A-associated GO terms across cancer lineages are Gonad development, CGMP catabolic process, and Negative regulation of reactive oxygen species metabolic process. Each is linked with PDE10A in more than 6 cancer types. Because this analysis shows association rather than direction, both PDE10A-to-partner and partner-to-PDE10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gonad development grouped by PDE10A-low versus PDE10A-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE10A→partner) and Y-score (partner→PDE10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Gonad development →	-0.055	-1.693	<.001	<.001	3	7
KIDNEY	CGMP catabolic process →	+1.507	+1.948	<.001	.002	3	6
OVARY	Negative regulation of reactive oxygen species metabolic process →	+0.058	+1.897	.009	.002	3	6
BLOOD_Lymphoma	Membrane depolarization during action potential →	-0.167	-0.724	<.001	.006	3	6
LUNG_NSCLC_LUAD	Digestive system process →	-0.102	-2.145	.005	.004	3	5
SKIN	Monocyte extravasation →	+0.767	+2.293	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,488 associations by consensus.

Gonad development by PDE10A expression — SKIN

Explore this box plot interactively →