PDE10A

Across TCGA cell cohorts, PDE10A mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE10A-associated genes across cancer lineages are EAF1, CHRM1, and ZFAND4. Each is linked with PDE10A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE10A-to-partner and partner-to-PDE10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EAF1 grouped by PDE10A-low versus PDE10A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE10A→partner) and Y-score (partner→PDE10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EAF1 →	+0.431	+2.502	.007	.005	3	2
LARGE_INTESTINE	CHRM1 →	+0.556	+2.502	<.001	.005	3	2
LARGE_INTESTINE	ZFAND4 →	+0.706	+2.502	.006	.005	3	2
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR13D1 →	+0.033	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

EAF1 by PDE10A expression — LARGE_INTESTINE

Explore this box plot interactively →