Across TCGA pan-cancer cohorts, PDCL3P5 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated PDCL3P5 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PDCL3P5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDCL3P5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

KIRP, ACC, and LGG are the cancer types where PDCL3P5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.507	0.836	<.001	128	view →
ACC	DFS	Tertile	II,III,IV	0.226	0.643	.003	66	view →
LGG	DFS	Median	All	0.637	0.830	<.001	54	view →
LUAD	OS	Median	III,IV	0.762	0.556	.003	52	view →
HNSC	DFS	Median	All	0.776	0.649	.002	50	view →
UVM	OS	Tertile	All	0.327	1.000	.004	45	view →
SKCM	OS	Tertile	All	0.453	0.295	.002	28	view →
KIRC	DFS	Tertile	II,III,IV	0.410	0.596	.008	23	view →
LAML	DFS	Quartile	All	0.572	0.302	.008	18	view →
COAD	DFS	Median	All	0.416	0.613	.008	17	view →
OV	DFS	Median	All	0.418	0.344	.012	16	view →
THCA	DFS	Tertile	II,III,IV	0.549	0.948	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

Exploration

Same gene, other analysis: PDCL3P5 tumor-vs-normal RNA expression · all PDCL3P5 data types