PDCL3

Across TCGA patient cohorts, PDCL3 mutation is significantly associated with the RNA expression of many other genes, with 113 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCL3-associated genes across cancer lineages are RNU4ATAC4P, MIR6893, and MAGEB10. Each is linked with PDCL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCL3-to-partner and partner-to-PDCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4ATAC4P grouped by PDCL3-low versus PDCL3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCL3→partner) and Y-score (partner→PDCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU4ATAC4P →	+0.142	+4.257	<.001	.007	3	2
BRCA	MIR6893 →	+0.530	+5.230	<.001	.007	3	1
COAD	MAGEB10 →	+0.842	+5.435	<.001	.005	3	1
UCEC	MIR8071-1 →	+1.357	+2.700	<.001	.004	3	1
UCEC	IGLL4P →	+0.526	+2.671	.007	.005	3	1
UCEC	MIR8071-2 →	+1.459	+2.935	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

RNU4ATAC4P by PDCL3 expression — LUSC

Explore this box plot interactively →