PDCL3

Across TCGA patient cohorts, PDCL3 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCL3-associated genes across cancer lineages are EGFR, p90 RSK, and C-Raf. Each is linked with PDCL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCL3-to-partner and partner-to-PDCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by PDCL3-low versus PDCL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCL3→partner) and Y-score (partner→PDCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.208	-3.000	.024	.037	3	1
UCEC	p90 RSK →	+0.280	+3.013	.011	.019	3	1
UCEC	C-Raf →	+0.164	+3.000	.048	.037	2	1
UCEC	PDK1_pS241 →	+0.227	+3.013	.021	.019	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

EGFR by PDCL3 expression — UCEC

Explore this box plot interactively →