PDCL3

Across TCGA cell cohorts, PDCL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,511 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PDCL3-associated GO terms across cancer lineages are DNA replication initiation, DNA-templated DNA replication, and Positive regulation of chromosome segregation. Each is linked with PDCL3 in more than 12 cancer types. Because this analysis shows association rather than direction, both PDCL3-to-partner and partner-to-PDCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by PDCL3-low versus PDCL3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCL3→partner) and Y-score (partner→PDCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.192	+0.721	.001	<.001	3	13
BLOOD_Lymphoma	DNA-templated DNA replication →	+0.098	+0.946	<.001	<.001	3	12
BLOOD_Lymphoma	Positive regulation of chromosome segregation →	+0.128	+0.839	<.001	<.001	3	12
PANCREAS	Ribosomal small subunit export from nucleus →	+0.110	+0.919	<.001	<.001	3	12
BLOOD_Myeloma	Positive regulation of translational elongation →	+0.100	+0.791	.006	.001	3	12
PANCREAS	Regulation of mitotic sister chromatid separation →	+0.130	+0.796	.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,511 associations by consensus.

DNA replication initiation by PDCL3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →