PDCD5

Across TCGA patient cohorts, PDCD5 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD5-associated genes across cancer lineages are eEF2, PDCD4, and TIGAR. Each is linked with PDCD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD5-to-partner and partner-to-PDCD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PDCD5-low versus PDCD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD5→partner) and Y-score (partner→PDCD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.499	+3.000	.015	.037	3	1
UCEC	PDCD4 →	-0.859	-3.000	.001	.037	3	1
UCEC	TIGAR →	+0.212	+3.026	.016	.019	3	1
UCEC	4E-BP1_pT37_T46 →	-0.594	-3.000	.006	.037	2	1
UCEC	Gab2 →	+0.488	+3.000	.018	.037	1	1
UCEC	Notch1 →	+0.316	+3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

eEF2 by PDCD5 expression — UCEC

Explore this box plot interactively →