PDCD4

Across TCGA patient cohorts, PDCD4 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD4-associated genes across cancer lineages are EGFR_pY1068, p62 Lck ligand, and eIF4E. Each is linked with PDCD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD4-to-partner and partner-to-PDCD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PDCD4-low versus PDCD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD4→partner) and Y-score (partner→PDCD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.334	-3.000	.001	.001	3	2
UCEC	p62 Lck ligand →	+0.277	+2.594	.039	.006	3	2
UCEC	eIF4E →	+0.234	+3.335	.007	.005	3	1
UCEC	Ku80 →	+0.225	+2.125	.021	.010	3	1
UCEC	MEK1 →	+0.337	+2.115	.025	.017	3	1
UCEC	Notch1 →	+0.124	+1.750	.033	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by PDCD4 expression — UCEC

Explore this box plot interactively →