PDCD2

Across TCGA patient cohorts, PDCD2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD2-associated genes across cancer lineages are EGFR_pY1068, FOXO3a_pS318_S321, and GAPDH. Each is linked with PDCD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD2-to-partner and partner-to-PDCD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PDCD2-low versus PDCD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD2→partner) and Y-score (partner→PDCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.253	-3.459	.045	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.177	-2.990	.004	.036	3	1
UCEC	GAPDH →	+0.565	+2.321	.036	.035	3	1
UCEC	p62 Lck ligand →	+0.493	+3.009	.002	.019	3	1
UCEC	PCNA →	+0.218	+2.321	.044	.034	3	1
UCEC	PDCD4 →	-0.577	-2.321	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

EGFR_pY1068 by PDCD2 expression — UCEC

Explore this box plot interactively →