Across TCGA patient cohorts, PDCD1LG2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD1LG2-associated genes across cancer lineages are EGFR_pY1068, FOXO3a_pS318_S321, and mTOR_pS2448. Each is linked with PDCD1LG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD1LG2-to-partner and partner-to-PDCD1LG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD1LG2→partner) and Y-score (partner→PDCD1LG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.302	-3.321	.012	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.154	-3.160	.010	.019	3	1
UCEC	mTOR_pS2448 →	-0.200	-2.986	.005	.035	3	1
UCEC	Notch1 →	+0.177	+2.459	.009	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.712	-2.446	.001	.020	3	1
UCEC	p38-MAPK →	-0.181	-2.459	.022	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

PDCD1LG2 survival (RNA) · tumor vs normal (RNA) · all PDCD1LG2 data types