PDCD11

Across TCGA patient cohorts, PDCD11 mutation is significantly associated with the RNA expression of many other genes, with 6,251 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD11-associated genes across cancer lineages are NPRL2, CDCA2, and NDUFA6. Each is linked with PDCD11 in more than 4 cancer types. Because this analysis shows association rather than direction, both PDCD11-to-partner and partner-to-PDCD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPRL2 grouped by PDCD11-low versus PDCD11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD11→partner) and Y-score (partner→PDCD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NPRL2 →	+0.224	+2.117	.002	.001	3	5
UCEC	CDCA2 →	+0.724	+1.691	<.001	<.001	3	4
COAD	NDUFA6 →	+0.493	+3.512	<.001	.002	3	4
STAD	ZNF511 →	+0.585	+2.338	<.001	.003	3	4
SKCM	WDHD1 →	+0.611	+2.273	<.001	.004	3	4
SKCM	ARHGAP11A →	+0.696	+1.851	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,251 associations by consensus.

NPRL2 by PDCD11 expression — UCEC

Explore this box plot interactively →