PDCD11

Across TCGA patient cohorts, PDCD11 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD11-associated genes across cancer lineages are STAT3_pY705, Annexin_VII, and Caspase-7-cleavedD198. Each is linked with PDCD11 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDCD11-to-partner and partner-to-PDCD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PDCD11-low versus PDCD11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD11→partner) and Y-score (partner→PDCD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.370	-2.378	<.001	<.001	3	3
STAD	Annexin_VII →	-0.129	-2.115	.045	.017	3	3
COAD	Caspase-7-cleavedD198 →	+1.419	+2.708	<.001	.003	3	3
UCEC	4E-BP1 →	+0.319	+1.765	<.001	<.001	3	3
COAD	GAPDH →	+0.506	+2.182	.013	.033	3	3
COAD	ASNS →	+0.446	+2.708	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

STAT3_pY705 by PDCD11 expression — UCEC

Explore this box plot interactively →