PDCD10

Across TCGA patient cohorts, PDCD10 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD10-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and FOXO3a. Each is linked with PDCD10 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD10-to-partner and partner-to-PDCD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PDCD10-low versus PDCD10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD10→partner) and Y-score (partner→PDCD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.108	-3.143	.011	.018	3	1
UCEC	EGFR_pY1068 →	-0.216	-1.700	.042	.044	3	1
UCEC	FOXO3a →	-0.108	-3.156	.011	.018	3	1
UCEC	ACC1 →	+0.306	+2.820	.047	.035	3	1
UCEC	JNK2 →	+0.195	+3.179	.021	.010	3	1
UCEC	MSH2 →	-0.273	-2.295	.005	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

14-3-3_beta by PDCD10 expression — UCEC

Explore this box plot interactively →