Across TCGA patient cohorts, PDCD1 protein abundance is significantly associated with the RNA expression of many other genes, with 558 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD1-associated genes across cancer lineages are CD274, EPSTI1, and CXCL9. Each is linked with PDCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD1-to-partner and partner-to-PDCD1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD1→partner) and Y-score (partner→PDCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD274 →	+1.392	+1.649	<.001	<.001	3	2
CCRCC	EPSTI1 →	+1.243	+0.931	<.001	<.001	3	2
UCEC	CXCL9 →	+3.879	+1.650	<.001	<.001	3	2
CCRCC	CD8A →	+3.255	+1.205	.001	.001	3	2
CCRCC	GBP5 →	+2.665	+1.144	<.001	.002	3	2
CCRCC	GBP4 →	+1.827	+1.144	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 558 associations by consensus.

Exploration

PDCD1 survival (RNA) · tumor vs normal (RNA) · all PDCD1 data types