Across TCGA patient cohorts, PDCD1 mutation is significantly associated with the RNA expression of many other genes, with 3,619 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD1-associated genes across cancer lineages are RN7SL83P, DAPK3, and MRPL57. Each is linked with PDCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD1-to-partner and partner-to-PDCD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD1→partner) and Y-score (partner→PDCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL83P →	+0.366	+4.392	<.001	.006	3	2
UCEC	DAPK3 →	+0.589	+3.119	<.001	<.001	3	2
UCEC	MRPL57 →	+0.316	+1.928	.004	.009	3	2
UCEC	GPR137 →	+0.426	+2.246	.003	.005	3	2
UCEC	REXO1 →	+0.455	+2.831	.003	.001	3	2
SKCM	RN7SL837P →	+0.049	+3.993	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,619 associations by consensus.

Exploration

PDCD1 survival (RNA) · tumor vs normal (RNA) · all PDCD1 data types