Across TCGA patient cohorts, PDCD1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD1-associated genes across cancer lineages are Cyclin-E2, INPP4B, and ATM. Each is linked with PDCD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDCD1-to-partner and partner-to-PDCD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD1→partner) and Y-score (partner→PDCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.267	+3.469	<.001	.002	3	3
UCEC	INPP4B →	-0.428	-2.687	.003	.006	3	2
UCEC	ATM →	-0.831	-2.700	<.001	.006	3	2
UCEC	eEF2 →	+0.451	+2.700	.005	.006	3	1
UCEC	EGFR_pY1068 →	-0.327	-3.459	.003	.005	3	1
UCEC	eIF4G →	+0.331	+2.321	.017	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

PDCD1 survival (RNA) · tumor vs normal (RNA) · all PDCD1 data types