Across TCGA cell cohorts, PDCD1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDCD1-associated genes across cancer lineages are TKTL2, BPY2, and BPY2B. Each is linked with PDCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD1-to-partner and partner-to-PDCD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD1→partner) and Y-score (partner→PDCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TKTL2 →	+0.046	+4.187	<.001	.002	3	1
LARGE_INTESTINE	BPY2 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2B →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2C →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	LRRD1 →	+0.036	+3.453	.001	.009	3	1
LUNG_NSCLC_LUAD	GPHB5 →	+0.039	+4.887	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

PDCD1 survival (RNA) · tumor vs normal (RNA) · all PDCD1 data types