PDC

Across TCGA patient cohorts, PDC mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PDC-associated genes across cancer lineages are GMP and Plasma cells. Each is linked with PDC in more than 1 cancer types. Because this analysis shows association rather than direction, both PDC-to-partner and partner-to-PDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by PDC-low versus PDC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDC→partner) and Y-score (partner→PDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GMP →	+0.054	+1.958	<.001	.029	3	1
SKCM	Plasma cells →	+0.020	+2.444	.049	.025	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

GMP by PDC expression — SKCM

Explore this box plot interactively →