PDC

Across TCGA cell cohorts, PDC RNA expression is significantly associated with the go_rna of many other GO terms, with 2,274 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDC-associated GO terms across cancer lineages are Regulation of RNA splicing, Negative regulation of myoblast fusion, and Negative regulation of translational initiation. Each is linked with PDC in more than 10 cancer types. Because this analysis shows association rather than direction, both PDC-to-partner and partner-to-PDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by PDC-low versus PDC-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDC→partner) and Y-score (partner→PDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of RNA splicing →	+0.064	+0.100	<.001	.003	3	11
BLOOD_Lymphoma	Negative regulation of myoblast fusion →	+0.099	+0.091	<.001	<.001	3	10
SOFT_TISSUE	Negative regulation of translational initiation →	+0.080	+0.058	<.001	.002	3	10
SOFT_TISSUE	Regulatory ncRNA-mediated gene silencing →	+0.086	+0.063	<.001	.003	3	9
KIDNEY	Regulation of cilium assembly →	+0.048	+0.040	<.001	<.001	3	9
SKIN	Negative regulation of calcium ion export across plasma membrane →	+0.042	+0.038	.002	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,274 associations by consensus.

Regulation of RNA splicing by PDC expression — BLOOD_Lymphoma

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