PDC-AS1

Across TCGA pan-cancer cohorts, PDC-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PDC-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PDC-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDC-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LUSC show a favorable association.

KIRC, UCEC, and LUAD are the cancer types where PDC-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.762	0.880	.001	64	view →
UCEC	DFS	Tertile	All	0.486	0.687	<.001	54	view →
LUAD	OS	Tertile	All	0.886	0.685	<.001	33	view →
UVM	OS	Median	III,IV	0.304	1.000	.008	19	view →
CHOL	DFS	Median	II,III,IV	0.117	0.501	.020	15	view →
THCA	DFS	Quartile	II,III,IV	0.725	0.919	.002	14	view →
LUSC	OS	Quartile	All	0.769	0.621	.005	14	view →
PRAD	DFS	Tertile	All	0.707	0.895	.007	12	view →
GBM	DFS	Median	All	0.384	0.196	.006	9	view →
READ	OS	Tertile	II,III,IV	1.000	0.843	.019	8	view →
KICH	OS	Quartile	III,IV	0.178	0.797	.042	7	view →
LAML	DFS	Median	All	0.506	0.625	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PDC-AS1–KIRC (DFS)

Open the KIRC breakdown →