Across TCGA patient cohorts, PCYT2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCYT2-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and Notch1. Each is linked with PCYT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCYT2-to-partner and partner-to-PCYT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCYT2→partner) and Y-score (partner→PCYT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.262	-2.999	.030	.035	3	1
UCEC	A-Raf_pS299 →	-0.209	-3.169	<.001	.019	3	1
UCEC	Notch1 →	+0.245	+3.335	<.001	.005	3	1
UCEC	p62 Lck ligand →	+0.510	+3.179	.001	.010	3	1
UCEC	TSC1 →	+0.240	+2.459	.003	.020	3	1
UCEC	VEGFR2 →	+0.507	+3.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

PCYT2 survival (RNA) · tumor vs normal (RNA) · all PCYT2 data types